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The original study was conducted in 1037 people aged 70-90 without dementia, 123 of whom had type 2 diabetes and 67 received metformin

 

In general, people with type 2 diabetes tend to have a higher risk of dementia - type 2 diabetes can lead to long-term health complications, including cognitive decline.

 

 

However, six years later, the statistics showed that the cognitive function of patients with type 2 diabetes mellitus who did not take metformin was significantly faster, and the risk of new onset dementia was 5 times higher than that of metformin users.

 

 

At the same time, it should be noted that compared with the non-diabetic population, there was no significant difference in the rate of cognitive decline in patients with type 2 diabetes who took metformin within 6 years.

 

 

Professor Katherine Samaras, endocrinologist at St. Vincent's Hospital in Sydney, the lead author of the study, said: "metformin is safe and widely used, and these data suggest its new potential. For patients with type 2 diabetes, metformin may bring cognitive health benefits beyond glucose control. More broadly, for people at high risk of dementia and their families, it could change their lives. "

 

 

Based on the preliminary findings of this study, the team is planning to conduct a large randomized controlled trial of metformin in high-risk people with dementia, and to assess changes in cognitive function within three years.

 

 

Potential multiple effects of Shenyao

 

 

In fact, previous studies have shown that metformin may play a role in human cognitive function, such as repairing brain damage and reversing cognitive impairment. Of course, metformin is considered a miracle drug because it does more than that. Up to now, metformin has been found to have more than 20 effects, such as weight loss, anti-aging and so on.

 

 

 

Metformin plays a role in reducing blood glucose mainly by inhibiting the production of glucose in the liver. For a long time, metformin has been the first-line drug for the treatment of type 2 diabetes, and it is also one of the most commonly used prescription drugs in the world. Here also have to remind a word, metformin as a hypoglycemic prescription drug, non - indications, do not use without authorization.

 

 

1. Weight loss

 

 

Metformin is a kind of hypoglycemic drug that can reduce weight. It can increase insulin sensitivity and reduce fat synthesis. For many type 2 sugar friends, weight loss itself is conducive to stable blood glucose control.

 

 

A study by the US diabetes prevention program (DPP) team showed that patients treated with metformin lost an average of 3.1 kg over a 7-8-year period in a non blinded study.

 

 

2. Anti aging effect

 

 

Recently, the U.S. Food and Drug Administration approved the clinical trial of "using metformin to fight aging". Foreign scientists may regard metformin as an anti-aging candidate drug because it can increase the amount of oxygen molecules released into cells. In principle, it seems to increase the body's strength and prolong its life span.

 

 

3. Reverse biological age

 

 

The official website of nature, an international science and technology journal, published a big news. A small clinical study in California has shown for the first time that reversing the human epigenetic clock is possible. Over the past year, nine healthy volunteers took a mixture of growth hormone and two diabetes drugs, including metformin. By analyzing the markers on a person's genome, their biological age has fallen by an average of 2.5 years.

 

 

4. Anti haze

 

 

Some research results show that the team led by professor Scott Budinger of Northwestern University has confirmed in mice that metformin can prevent inflammation caused by haze, prevent immune cells from releasing a dangerous molecule into the blood, inhibit the formation of arterial thrombosis, and thus reduce the risk of cardiovascular disease.

 

 

5. Help quit smoking

 

 

Researchers at the University of Pennsylvania found that long-term nicotine use activates the AMPK signaling pathway, which is inhibited during nicotine withdrawal. Therefore, they concluded that if the AMPK signaling pathway was activated with drugs, the withdrawal reaction might be alleviated.

 

 

Metformin is an AMPK agonist. When the researchers gave metformin to mice that had a nicotine withdrawal response, they found that it alleviated the withdrawal reaction in mice. Their research shows that metformin can be used to help quit smoking.

 

 

6. Anti inflammatory

 

Some preclinical and clinical studies have shown that metformin can not only improve chronic inflammation by improving metabolic parameters such as hyperglycemia, insulin resistance and dyslipidemia leading to atherosclerosis, but also has direct anti-inflammatory effect.

 

 

Studies have shown that metformin can inhibit inflammatory response, mainly through amp activated protein kinase (AMPK) - dependent or independent inhibition of nuclear transcription factor B (NFB).